KMID : 1197720160090010035
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´ëÇÑÆÄŲ½¼º´ ¹× ÀÌ»ó¿îµ¿Áúȯ ÇÐȸÁö 2016 Volume.9 No. 1 p.35 ~ p.39
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N30 Somatosensory Evoked Potential Is Negatively Correlated with Motor Function in Parkinson¡¯s Disease
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Kang Suk-Yun
Ma Hyeo-Il
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Abstract
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Objective: The aim of this study was to investigate frontal N30 status in Parkinson¡¯s disease (PD) and to examine the correlation between the amplitude of frontal N30 and the severity of motor deficits.
Methods: The frontal N30 was compared between 17 PD patients and 18 healthy volunteers. Correlations between the amplitude of frontal N30 and the Unified Parkinson¡¯s Disease Rating Scale (UPDRS) motor score of the more severely affected side was examined.
Results: The mean latency of the N30 was not significantly different between patients and healthy volunteers (p = 0.981), but the mean amplitude was lower in PD patients (p < 0.025). There was a significant negative correlation between the amplitude of N30 and the UPDRS motor score (r = -0.715, p = 0.013).
Conclusions: The frontal N30 status indicates the motor severity of PD. It can be a useful biomarker reflecting dopaminergic deficits and an objective measurement for monitoring the clinical severity of PD.
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KEYWORD
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Parkinson¡¯s disease, Evoked potentials, Somatosensory, N30, Unified Parkinson¡¯s Diseases Rating Scale, Motor
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